Background/purpose: The purpose of the study was to determine absolute and relative rates of venous thromboembolism (VTE) following general surgical procedures in children compared to the general population. \ud\udMethods: We analyzed data from all patients under the age of 18 years in the Clinical Practice Research Datalink, linked to Hospital Episode Statistics from England (2001–2011) undergoing a general surgical procedure and population controls. Crude rates of VTE and adjusted hazard ratios were calculated using Cox regression. Results We identified 15,637 children who had a surgical procedure with 161,594 controls. Six children undergoing surgery had a VTE diagnosed in the year after compared to five children in the population cohort. The overall rate of VTE following surgery was 0.4 per 1000 person years (pyrs) (95% confidence interval [CI] 0.15–0.88) compared to 0.04 per 1000 pyrs (95% CI 0.02–0.09) in the population cohort. This represented a 9 fold increase in risk compared to the population cohort (adjusted hazard ratio [HR] 8.80; 95% CI 2.59–29.94). \ud\udConclusions Children are at increased risk for VTE following general surgical procedures compared to the general population however the absolute risk is small and given this the benefits of thromboprophylaxis need to be balanced against the risk of complications following its use.
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机译：背景/目的：本研究的目的是确定与一般人群相比，儿童一般外科手术后静脉血栓栓塞（VTE）的绝对和相对发生率。 \ ud \ ud方法：我们在临床实践研究数据链中分析了所有18岁以下患者的数据，这些数据与接受常规外科手术和人口控制的英格兰（2001-2011）医院情节统计数据相关。使用Cox回归来计算VTE的粗略率和调整后的危险比。结果我们确定了15637名接受了161594例手术的儿童。与人口队列中的五名儿童相比，一年后有六名接受手术的儿童被诊断出患有静脉血栓栓塞。手术后VTE的总体发生率为每1000人年0.4（pyrs）（95％置信区间[CI] 0.15–0.88），而该人群的总VTE率为0.04每1000人年（95％CI 0.02–0.09）。与人群相比，这意味着风险增加了9倍（调整后的危险比[HR] 8.80； 95％CI 2.59-29.94）。 \ ud \ ud结论与一般人群相比，一般手术后儿童发生VTE的风险增加，但是绝对风险很小，因此，应权衡预防血栓预防的益处和使用其后发生并发症的风险。
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